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Determination of hydroxycarbamates in aqueous matrices by direct derivatization and GC-MS analysis in chemical ionization mode

✍ Scribed by Vincenti, Marco ;Minero, Claudio ;Lago, Stefania ;Rovida, Costanza

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
395 KB
Volume
18
Category
Article
ISSN
0935-6304

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✦ Synopsis

Abstract

A rapid and effective procedure, developed for the determination of polar compounds in water, has been applied to hydroxycarbamates. In few minutes, it is possible to perform a catalyzed derivatization of such compounds directly in the aqueous medium, using n‐hexyl chloroformate. Extraction with n‐hexane and injection into a benchtop GC‐MS system are the only two further steps to complete the analysis. Chemical ionization proved to be more effective than electron impact to produce valuable mass spectra in terms of selectivity and sensitivity. Linear quantitative responses were demonstrated over a two‐order‐of‐magnitude range. The minimum detectable concentration was 3 ppb for acetohydroxamic acid and 10 ppb for hydroxyurethane, obtained from Po river water samples spiked with the two hydroxycarbamate standards.

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