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Determination of End Point of Primary Drying in Freeze-Drying Process Control

โœ Scribed by Sajal M. Patel; Takayuki Doen; Michael J. Pikal


Book ID
111768106
Publisher
Springer US
Year
2010
Tongue
English
Weight
235 KB
Volume
11
Category
Article
ISSN
1530-9932

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This paper deals with the design space of a pharmaceutical freeze-drying process. Mathematical modeling is used to investigate the effect of the operating conditions [shelf temperature (T shelf ) and chamber pressure (P c )] on product temperature (that has to remain below a limit value) and sublima