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Determination of enantiomeric purity of alcohols using achiral diphenyldichlorosilane

โœ Scribed by Xuebao Wang


Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
220 KB
Volume
32
Category
Article
ISSN
0040-4039

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๐Ÿ“œ SIMILAR VOLUMES


Determination of absolute configuration
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Absolute configuration and enantiomeric purities of some hydroxyketones and diols of spiro[4\_4]nonane and 2,2'-spirobi-indan can be simultaneously determined by use of MTPA derivatives and a lanthanoid shift reagent.

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The enantiomeric purity of primary-secondary glycols, RCHOHCH2OH, is conveniently determined by conversion to a pair of epimeric 1,3-dioxolanes through condensation with bensaldehyde, followed by nmr spectroscopy in presence of a chiral shift reagent with observation of the bensylic protons.

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Sumnary: Enantlomenc purities of axially choral biaryls with hydroxyl, amino, and carboxyl groups can be easily determlned by pmr spectra using MTPA derivatives and shift reagent. Recently, Behnam et al. have reported' that the methyl proton signals in racemlc biaryls such as dimethyl 6,6'-dlmethoxy