Chromatographic determination of enantiomeric purity by achiral means
β Scribed by Lennart Hansson; Roland Isaksson
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 482 KB
- Volume
- 653
- Category
- Article
- ISSN
- 1873-3778
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π SIMILAR VOLUMES
The enantiomeric purity of primary-secondary glycols, RCHOHCH2OH, is conveniently determined by conversion to a pair of epimeric 1,3-dioxolanes through condensation with bensaldehyde, followed by nmr spectroscopy in presence of a chiral shift reagent with observation of the bensylic protons.
Sumnary: Enantlomenc purities of axially choral biaryls with hydroxyl, amino, and carboxyl groups can be easily determlned by pmr spectra using MTPA derivatives and shift reagent. Recently, Behnam et al. have reported' that the methyl proton signals in racemlc biaryls such as dimethyl 6,6'-dlmethoxy