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Determination of Broxaterol in Plasma by Coupled HPLC-GC

✍ Scribed by Gianesello, V. ;Bolzani, L. ;Brenn, E. ;Gazzaniga, A.

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
284 KB
Volume
11
Category
Article
ISSN
0935-6304

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✦ Synopsis

For the analysis of broxaterol 1 -(3-bromoisoxazol-5-yl)-2-(tert-buty1amino)ethanol in human plasma and urine an on-line HPLC-GC apparatus was used applying the "concurrent solvent evaporation'' technique described in previous studies. Broxaterol is quantitatively determined by capillary GC with ECD detection, after extraction from plasma and derivatization. The detection limit of 0.03 ng/ml permits pharmacokinetic studies in man after oral and intravenous administration of the drug.

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