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Determination of anti-inflammatory drugs and estrogens in water by HPLC with UV detection

✍ Scribed by Anna Stafiej; Krystyna Pyrzynska; Fiona Regan

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
569 KB
Volume
30
Category
Article
ISSN
1615-9306

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✦ Synopsis

Abstract

An analytical method based on LC and UV detection has been developed for the determination of anti‐inflammatory compounds and estrogens in water samples. The drugs investigated were diclofenac, ketoprofen, ibuprofen, naproxen, clofibric acid, estriol, 17β‐estradiol, estrone and ethynylestradiol. The detection limits were in the range of 6–74 μg/L and 0.041–0.16 mg/L for acidic pharmaceuticals and estrogens, respectively, using narrow‐bore C18 analytical column. Analyte enrichment from water samples was achieved by SPE procedure using polymeric Strata‐X cartridges. Average recoveries obtained from 2.5 L of surface water sample were in the range of 77–98%.

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