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Determination of absolute configuration of trans-2-arylcyclohexanols using remarkable aryl-induced 1H NMR shifts in diastereomeric derivatives

โœ Scribed by Masato Matsugi; Kinuyo Itoh; Masatomo Nojima; Yuri Hagimoto; Yasuyuki Kita

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
110 KB
Volume
42
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A facile determination of the absolute configuration of trans-2-arylcyclohexanols was achieved. It takes advantage of the observations of the remarkable aryl-induced 1 H NMR shifts that seems to be ascribable to the discrimination of the diastereo-environment between intermediary optically active diastereomers by intramolecular CH/p interaction.

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