𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Determination of 7-bromo-1,3-dihydro-5-(2-pyridyl)-2h-1,4-benzodiazepin-2-one (ro 5-3350) in blood by gas-liquid chromatography

✍ Scribed by J. Arthur; F. DeSilva; J. Kaplan

Publisher
John Wiley and Sons
Year
1966
Tongue
English
Weight
493 KB
Volume
55
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

The synthesis of 7-chloro-1-methyl-5-phe
The synthesis of 7-chloro-1-methyl-5-phenyl-1, 3-dihydro-2H-1,4-benzodiazepin-2-one-5-14C and 7-nitro-1-methyl-5-(2′-fluorophenyl)-1, 3-dihydro-2H-1,4-benzodiazepin-2-one-5-14C
✍ H. H. Kaegi; W. Burger; C. J. Bader 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 393 KB 👁 1 views

## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbon‐14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^C‐benzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des

The preparation of 7-chloro-5-(2-chlorop
The preparation of 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one-5-14C
✍ H. H. Kaegi; W. Burger 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 168 KB 👁 1 views

## Abstract 7‐Chloro‐5‐(2‐chlorophenyl)‐1,3‐dihydro‐2H‐1,4‐benzodiazepin‐2‐one labeled with carbon‐14 in carbon 5 of the diazepine ring has been synthesized. The compound was prepared in a multistep synthesis from barium carbonate‐^14^C in an overall yield of 23%.

Synthesis of 7-chloro-1,3-dihydro-5-(2-f
Synthesis of 7-chloro-1,3-dihydro-5-(2-fluorophenyl)-1-methyl-2H-1,4-benzodiazepin-2-one-5-14C (fludiazepam-14C)
✍ Iwao Nakatsuka; Kazuo Kawahara; Takeshi Kamada; Fumiaki Shono; Akira Yoshitake 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 French ⚖ 298 KB 👁 1 views

## Abstract 7‐Chloro‐1,3‐dihydro‐5‐(2‐fluorophenyl)‐1‐methyl‐2H‐1,4‐benzodiazepin‐2‐one (Fludiazepam) (I), an anti‐anxiety agent, was labelled with carbon‐14 at C‐5 position for metabolic studies. The reaction sequence for the synthesis is shown in Fig. 2. o‐Fluorobenzoic‐^14^C acid (IV) was prepar

Synthesis of 1, 3-dihydro-1-methyl-7-nit
Synthesis of 1, 3-dihydro-1-methyl-7-nitro-5-phenyl-2H-1, 4-benzodiazepin-2-one-5-14c (nimetazepam-5-14C)
✍ A. Yoshitake; Y. Makari; M. Endo 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 French ⚖ 243 KB 👁 1 views

## Abstract The synthesis from carbon‐^14^C dioxide of 1, 3‐dihydro‐1‐methyl‐7‐nitro‐5‐phenyl‐2H‐1, 4‐benzodiazepin‐2‐one‐5‐^14^C (I) for use in metabolic studies has been described. The synthesis was achieved by the sequence shown in figure 1. The overall yield of labelled nimetazepam (I) was near