## Abstract 7‐Chloro‐5‐(2‐chlorophenyl)‐1,3‐dihydro‐2H‐1,4‐benzodiazepin‐2‐one labeled with carbon‐14 in carbon 5 of the diazepine ring has been synthesized. The compound was prepared in a multistep synthesis from barium carbonate‐^14^C in an overall yield of 23%.
Dose-dependent pharmacokinetics of 7-chloro-1,3-dihydro-5-(2′-chlorophenyl)-2h-1,4-benzodiazepin-2-one in dogs
✍ Scribed by Masaharu Konishi
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 236 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0022-3549
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## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbon‐14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^C‐benzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des
## Abstract 7‐Chloro‐1,3‐dihydro‐5‐(2‐fluorophenyl)‐1‐methyl‐2H‐1,4‐benzodiazepin‐2‐one (Fludiazepam) (I), an anti‐anxiety agent, was labelled with carbon‐14 at C‐5 position for metabolic studies. The reaction sequence for the synthesis is shown in Fig. 2. o‐Fluorobenzoic‐^14^C acid (IV) was prepar
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