✦ LIBER ✦

Determination and stability of sex

✍ Scribed by Chris Ottolenghi; Manuela Uda; Laura Crisponi; Shakib Omari; Antonio Cao; Antonino Forabosco; David Schlessinger

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 240 KB
Volume: 29
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.20515

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

How is the embryonic bipotential gonad regulated to produce either an ovary or a testis? In males, transient early activation of the Y chromosome Sry gene makes both germ cells and soma male. However, in females, available evidence suggests that the process of ovary sex determination may take place independently in the germline and somatic lineages. In addition, in contrast to testis, in ovary somatic cells, female‐to‐male gonadal sex reversal can occur at times throughout ovary development and maturation. We suggest that a single gene pathway, likely hinging on the Foxl2 transcription factor, both initiates and maintains sex differentiation in somatic cells of the mammalian ovary. BioEssays 29: 15–25, 2007. Published 2006 Wiley Periodicals, Inc.

📜 SIMILAR VOLUMES

Human sex determination

✍ Sinclair, Andrew H. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 90 KB 👁 1 views

Human sex determination is a fascinating topic, particularly at the level of molecular genetics, as it represents an excellent paradigm for mammalian organ development. Recent progress has seen the addition of several new pieces to this developmental jigsaw puzzle. In mammals, the Y chromosome is ma

Sex determination and the Y chromosome

✍ McElreavey, Ken; Fellous, Marc 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 39 KB 👁 2 views

Although SRY was first identified 10 years ago, we still know remarkably little about its mode of action or downstream target genes. Recently, potential protein partners have been identified and there has been considerable activity to understand the roles of WT1, SF-1, DAX-1 and SOX9 in gonadogenesi

Sex determination using PCR

✍ Peter E. Kima; Madeline E. Rasche 📂 Article 📅 2004 🏛 The American Society for Biochemistry and Molecula 🌐 English ⚖ 89 KB 👁 1 views

Determination of sex from the Tibia

✍ M. Yaşar İşcan; Patricia Miller-Shaivitz 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 373 KB 👁 2 views

Determination of sex from the hyoid bone

✍ Sarah C. Kindschuh; Tosha L. Dupras; Libby W. Cowgill 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 116 KB 👁 2 views

The arguable propriety of preconceptual

The arguable propriety of preconceptual sex determination

✍ Karp, Laurence E. 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 171 KB 👁 2 views