✦ LIBER ✦

Sex determination and the Y chromosome

✍ Scribed by McElreavey, Ken; Fellous, Marc

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 39 KB
Volume: 89
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19991229)89:4<176::aid-ajmg2>3.0.co;2-b

No coin nor oath required. For personal study only.

✦ Synopsis

Although SRY was first identified 10 years ago, we still know remarkably little about its mode of action or downstream target genes. Recently, potential protein partners have been identified and there has been considerable activity to understand the roles of WT1, SF-1, DAX-1 and SOX9 in gonadogenesis. The emerging picture is one of complex interactions, involving both positive and negative regulatory signals that, depending on the cellular and promoter context, drive the expression of male-specific genes. Despite recent advances, however, we are still unable to explain the genetic cause of most cases of 46,XY gonadal dysgenesis or even a single case of Y-chromosome-negative 46,XX maleness.

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