Detection of translocations affecting the BCL6 locus in B cell non-Hodgkin’s lymphoma by interphase fluorescence in situ hybridization
✍ Scribed by Sanchez-Izquierdo, D; Siebert, R; Harder, L; Marugan, I; Gozzetti, A; Price, H P; Gesk, S; Hernandez-Rivas, J M; Benet, I; Solé, F
- Book ID
- 110054969
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 367 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0887-6924
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Deletions of the long arm of chromosome 6 (6q) are among the most frequent chromosome aberrations in malignant lymphomas and often occur as secondary changes in addition to typical translocations, such as t(14;18). Using fluorescence in situ hybridization (FISH) with two YAC probes hybridizing to 6q
## BACKGROUND. The cytomorphologic diagnosis of mantle cell lymphoma (MCL) can be difficult and requires ancillary studies for accurate subclassification. More than 95% of MCLs are known to carry the t(11;14) chromosomal translocation. However, traditional cytogenetic studies on cytologic material