Detection of TP53 gene mutations in human sarcomas
✍ Scribed by J.S. Castresana; M.-P. Rubio; L. Gómez; A. Kreicbergs; A. Zetterberg; C. Barrios
- Book ID
- 116166292
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 724 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0959-8049
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The p53 gene (TP53) is mutated in numerous human cancers. We have used it as a molecular target to characterize the induction of mutations in human skin cancers. About 50% of all skin cancers in normal individuals exhibit p53 mutations. This frequency rises to 90% in skin cancers of patients with th
Three germline mutations in the TP53 tumor-suppressor gene are reported, two of which are not reported previously. A missense mutation at codon 265 of TP53 was found in three patients of a family that complied with the definition of the Li-Fraumeni syndrome. A nonsense mutation in codon 306 was foun