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Detection of the carcinogen 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) in beer and wine

✍ Scribed by Manabe, Shigeo; Suzuki, Hiramitsu; Wada, Osamu; Ueki, Akira


Book ID
118169148
Publisher
Oxford University Press
Year
1993
Tongue
English
Weight
230 KB
Volume
14
Category
Article
ISSN
0143-3334

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Synthesis of deuterated 2-amino-1-methyl
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## Abstract The syntheses of the deuterium‐labeled food mutagen 2‐amino‐1‐methyl‐6‐phenyl‐1H‐imidazo[4,5‐b]pyridine (PhIP) and its __N__‐hydroxy metabolite are described. Unlabeled PhIP is deuterated using a boron trifluoride phosphoric acid complex in one step. Labeled PhIP–^2^H~5~ is nitrosated t