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Detection of single base substitutions in total genomic DNA

✍ Scribed by Myers, Richard M.; Lumelsky, Nadya; Lerman, Leonard S.; Maniatis, Tom


Book ID
109738030
Publisher
Nature Publishing Group
Year
1985
Tongue
English
Weight
552 KB
Volume
313
Category
Article
ISSN
0028-0836

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DNA microarray technology holds significant promise for human DNA diagnostics. A number of technical approaches directed at the parallel identification of mutations or single nucleotide polymorphisms make use of polymerase-based specificity, like minisequencing or allele-specific primer elongation.