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Detection of point mutations by solid-phase methods

✍ Scribed by Ann-Christine Syvänen; Ulf Landegren

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
861 KB
Volume
3
Category
Article
ISSN
1059-7794

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✦ Synopsis

Several techniques exist that permit the efficient distinction among characterized DNA sequence variants. In this review we discuss a number of such analytic procedures. These techniques all take advantage of a variety solid supports to prepare and analyze reaction products. The described diagnostic principles are now being applied for the development of miniaturized assay formats, suitable for automated detection of large sets of sequences in clinical samples. o

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