Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10
β Scribed by Micaela Poetsch; Gerd Lorenz; Britta Kleist
- Book ID
- 114135174
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 115 KB
- Volume
- 132
- Category
- Article
- ISSN
- 0165-4608
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π SIMILAR VOLUMES
## Loss of heterozygosity (LOH ) at chromosome band 10q23 occurs frequently in a wide variety of human tumors. A recently identified candidate tumor suppressor gene, PTEN located on 10q23, is mutated in multiple advanced cancers. To explore whether PTEN is associated with human squamous cell carci
## Abstract ## Background. __ZAC/Lot1__ is a previously identified candidate tumor suppressor gene. The gene maps to the human chromosome 6q24βq25, a region frequently deleted in squamous cell carcinomas of the head and neck and other solid tumors. ## Methods. We have used a model of head and ne