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Detection of microcystins using electrospray ionization high-field asymmetric waveform ion mobility mass spectrometry/mass spectrometry

โœ Scribed by Barbara Ells; Kenneth Froese; Steve E. Hrudey; Randy W. Purves; Roger Guevremont; David A. Barnett

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
101 KB
Volume
14
Category
Article
ISSN
0951-4198

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โœฆ Synopsis

A combination of electrospray ionization, high-field asymmetric waveform ion mobility spectrometry, and mass spectrometry (ESI-FAIMS/MS) was used to analyze standard solutions of microcystins-LR, -RR, and -YR. The ability of FAIMS to separate ions in the gas phase reduced the amount of background in the mass spectrum without compromising the absolute signal for these microcystins. This reduction in background resulted in a ten-fold improvement in the signal-to-background ratio over conventional ESI-MS. Detection limits, using direct infusion, were determined to be 4, 2, and 1 nM for microcystins-LR, -RR, and -YR, respectively.

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Figure 3. Deconvoluted spectra of rat brain calbindin D 28K showing (A) the apoprotein and (B) the holoprotein showing four calcium bound.