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Detection of metabolic heterogeneity of human intracranial tumors in vivo by 1h nmr spectroscopic imaging

✍ Scribed by Christoph M. Segebarth; Danielle F. Balériaux; Peter R. Luyten; Jan A. Den Hollander

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
855 KB
Volume
13
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Patients with intracranial tumors (gliomas) were examined by means of localized water‐suppressed ^1^H NMR single volume spectroscopy and spectroscopic imaging. The ^1^H NMR spectra of the tumors exhibit signal intensities of the N‐acetyl aspartate, choline compounds, and creatine plus phosphocreatine resonance lines that are different from the corresponding intensities observed on normal brain tissue. Also, for 6 out of the 10 patients examined so far, lactate resonance lines were detected in the tumor spectra. For one patient, abnormal ^1^H NMR spectra were obtained of a hemisphere which appeared normal with ^1^H NMR imaging. Metabolic heterogeneity of the tumorous regions could be demonstrated with ^1^H NMR spectroscopic imaging, using a spatial resolution in the order of 1 cm. These results suggest a spectrum of metabolic observations that may ultimately provide an important means for characterizing brain tumors.

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