31P-{1H} echo-planar spectroscopic imaging of the human brain in vivo

✍ Scribed by M. Ulrich; T. Wokrina; G. Ende; M. Lang; P. Bachert

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 516 KB
• Volume: 57
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.21192

✦ Synopsis

Abstract

Echo‐planar spectroscopic imaging (EPSI) is one of the fastest spectroscopic imaging (SI) methods. It has been applied to ^1^H MR spectroscopy (MRS) studies of the human brain in vivo. However, to our knowledge, EPSI with detection of the ^31^P nucleus to monitor phosphorus‐containing neurometabolites has not yet been considered. In this work, eight different ^31^P‐{^1^H} EPSI sequence versions with spectral widths ranging from 313 Hz to 2.27 kHz were implemented on a clinical 1.5T whole‐body MR tomograph. The sequence versions utilized the heteronuclear nuclear Overhauser effect (NOE) for ^31^P signal enhancement. The sensitivity observed in experiments with model solutions was in good agreement with theoretical predictions. In vivo measurements performed on healthy volunteers (N = 16) demonstrated the feasibility of performing two‐dimensional (2D) ^31^P‐{^1^H} EPSI in the human brain, and the technique enabled fast acquisition of well‐resolved localized spectra. Magn Reson Med 57:784–790, 2007. © 2007 Wiley‐Liss, Inc.