In Vivo31P Echo-Planar Spectroscopic Imaging of Human Calf Muscle

✍ Scribed by Thomas Wilhelm; Peter Bachert

• Publisher: Elsevier Science
• Year: 2001
• Tongue: English
• Weight: 112 KB
• Volume: 149
• Category: Article
• ISSN: 1090-7807
• DOI: 10.1006/jmre.2001.2288

✦ Synopsis

Localized phosphorus-31 NMR spectra of human calf muscle in vivo were obtained by means of echo-planar spectroscopic imaging (EPSI) with a 1.5-T whole-body scanner. The technique permits the measurement of two-dimensional 31 P SI data at a minimum acquisition time of 2.4 s (8 × 8 voxels, TR = 300 ms). With 9.4 min measurement time (TR = 1100 ms, 64 averages) and 25 × 25 × 40 mm spatial resolution in vivo the 31 P NMR signal-to-noise ratio (S/N) of the phosphocreatine (PCr) resonance was about 45; the multiplets of nucleoside 5 -triphosphates were resolved. Spectral quality permits quantitative assessment of the PCr signal in a measurement time that is shorter by a factor of 2 or more than the minimum measurement time feasible with chemical-shift imaging. In a functional EPSI study with a time resolution of 20.5 s on the calf muscle of volunteers, spectra showed a 40% decrease of the PCr signal intensity (at rest: S/N ∼ = 12) upon exertion of the muscle.