Detection of HER-2/neu (c-erb B-2) DNA amplification in primary breast carcinoma : Interobserver reproducibility and correlation with immunohistochemical HER-2 overexpression
โ Scribed by Hitoshi Tsuda; Futoshi Akiyama; Hiroshi Terasaki; Tadashi Hasegawa; Masafumi Kurosumi; Mitsunobu Shimadzu; Shunji Yamamori; Goi Sakamoto
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 593 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0008-543X
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๐ SIMILAR VOLUMES
A PCR assay using capillary electrophoresis was designed for the detection of c-erbB-2 gene amplification in alcoholformalin-acetic acid (AFA)-fixed, paraffin-embedded biopsies from 81 consecutive breast tumors. c-erbB-2 expression was analyzed in the same samples using immuno-histochemistry (IHC).
## Abstract ## BACKGROUND The objective of this article was to compare five tumor markers between white women in the U.S. and native Korean women with earlyโonset breast carcinoma. ## METHODS Sixty Korean women who were diagnosed with breast carcinoma at age 45 years or younger and 60 white wome