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Combined detection of Her2/neu gene amplification and protein overexpression in effusions from patients with breast and ovarian cancer

✍ Scribed by Birgitta Schlüter; Roswitha Gerhards; Dirk Strumberg; Rudolf Voigtmann

Publisher
Springer-Verlag
Year
2010
Tongue
English
Weight
709 KB
Volume
136
Category
Article
ISSN
1432-1335

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## Abstract ## BACKGROUND The HER‐2 (Human Epidermal Growth factor receptor‐2, also known as c‐__erb__‐2/__neu__) protooncogene encodes a transmembrane receptor protein, __M__~r~ 185,000. Studies have shown that the HER‐2 oncogene is overexpressed in approximately 25–30% of ovarian carcinoma (OC)