## Abstract Metabolic activation of a drug leading to reactive metabolite(s) that can covalently modify proteins is considered an initial step that may lead to drug‐induced organ toxicities. Characterization of reactive metabolites is critical to designing new drug candidates with an improved toxic
Detection of Functional Ricin by Immunoaffinity and Liquid Chromatography−Tandem Mass Spectrometry
✍ Scribed by Becher, F.; Duriez, E.; Volland, H.; Tabet, J. C.; Ezan, E.
- Book ID
- 121194817
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 110 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0003-2700
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Tetrodotoxin (TTX), a powerful sodium channel blocker, usually exists as a mixture of its analogs (TTXs) in natural sources. Due to the structural variation, some analogs are difficult to detect using the postcolumn liquid chromatography-fluorescent detection (LC-FLD) system. Liquid chromatography/e
ConÐrmation methods based on the combination of immunoaffinity chromatography for sample clean-up and on-line liquid chromatography/mass spectrometry with electrospray ionization in both selected ion monitoring (SIM) and multiple reaction monitoring (MRM) modes were developed for the determination o