Detection of Epstein-Barr Virus–Derived Latent Membrane Protein-1 Gene in Various Head and Neck Cancers: Is It Specific for Nasopharyngeal Carcinoma?
✍ Scribed by Ngan-Ming Tsang; Kai-Ping Chang; Shinn-Yn Lin; Sheng-Po Hao; Chen-Kan Tseng; Tseng-tong Kuo; Ming-Hsui Tsai; Tsao-Chuen Chung
- Book ID
- 110084378
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 294 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0023-852X
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We reported previously that a characteristic Epstein-Barr virus latent membrane protein 1 (EBV-LMP1) gene was associated with nasopharyngeal carcinoma (NPC) in Hong Kong. It showed a 30 bp deletion at the carboxyl terminus with specific amino acid substitution Asp at codon 335 with reference to Gly
## Abstract ## Background Nasopharyngeal carcinoma (NPC) is associated with Epstein–Barr virus (EBV) infection. We previously found that interleukin (IL)‐1α and IL‐1β significantly increased in NPC tissues. This study investigated what EBV‐encoded proteins were involved in such IL‐1 production. #
## Abstract Latent membrane protein 1 (LMP‐1) is an Epstein‐Barr virus‐encoded oncoprotein expressed in ∼50–70% of nasopharyngeal carcinoma (NPC). Previous studies have shown that NPC‐derived LMP‐1 variants carrying 30 bp deletion and specific mutations in the 3′C‐terminal region confer high oncoge