The 30-bp Deletion of Epstein-Barr Virus Latent Membrane Protein-1 Gene Has No Effect in Nasopharyngeal Carcinoma
β Scribed by Kai-Ping Chang; Sheng-Po Hao; Shinn-Yn Lin; Shir-Hwa Ueng; Ping-Ching Pai; Chen-Kan Tseng; Chuen Hsueh; Meng-Shu Hsieh; Jau-Song Yu; Ngan-Ming Tsang
- Book ID
- 110087999
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 281 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0023-852X
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## Abstract Latent membrane protein 1 (LMPβ1) is an EpsteinβBarr virusβencoded oncoprotein expressed in βΌ50β70% of nasopharyngeal carcinoma (NPC). Previous studies have shown that NPCβderived LMPβ1 variants carrying 30 bp deletion and specific mutations in the 3β²Cβterminal region confer high oncoge
## Abstract Nasopharyngeal carcinoma, a malignancy associated closely with EpsteinβBarr virus (EBV), is prevalent among Chinese of Southern China origin. Epidemiological studies indicate a high prevalence of EBV in Asia with viral isolates having typical characteristics of the putative viral oncoge
## Abstract There are two types of Epstein Barr virus (EBV): EBVβ1 and EBVβ2, distinguished by genomic polymorphism in the genes encoding the nuclear antigens (EBNAβ2, β3A, β3B, β3C). Latent membrane protein 1 (LMPβ1) is an EBV protein with known oncogenic properties. Different variants had been de