✦ LIBER ✦

Detection and persistence of specific iga antibodies in serum of patients with hepatitis A by capture radioimmunoassay

✍ Scribed by Emanuel Sikuler; Arieh Keynan; Negba Hanuka; Maureen G. Friedman; Dr. Israel Sarov

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 471 KB
Volume: 11
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890110404

No coin nor oath required. For personal study only.

✦ Synopsis

The serum immunoglobulin A (IgA) response to hepatitis A virus (HAV) was investigated with a sensitive capture radioimmunoassay. In serial serum samples drawn from 15 patients with viral hepatitis A, IgA anti-HAV antibodies reached their highest titer between 1-2 weeks after onset and peak titers ranged from 10,000-20,000. Serum samples were available from six patients 30-32 months after onset of illness. These samples were all positive for IgA anti-HAV and some had titers similar to peak titers during illness. However, the height of the titration curves, expressed as the binding ratio (BR) at a dilution of 1/1000, was in all cases significantly lower at 30-32 months than during acute illness and early convalescence. The significance of the persistence of the IgA anti-HAV and possible reasons for the change in the BR are discussed.

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