Detection and its clinical value of minimal residual diseases in acute promyelocytic leukemia
β Scribed by Guo-sheng Jiang; Tian-hua Tang; Ke-hong Bi; Yu-kun Zhang; Hai-quan Ren; Liang-yu Zhao; Gui-yue Guo; Xiu-lan Liu; Qing-hua Ren; Feng-qin Jiang; Chuan-fang Liu; Jun Peng; Zhi-gang Tian
- Book ID
- 107466649
- Publisher
- Chinese Anti-Cancer Association
- Year
- 2002
- Tongue
- English
- Weight
- 370 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1000-9604
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Patients with acute leukemia in clinical remission may still have up to 10 10 residual malignant cells (the upper limit of detection by standard morphologic techniques). Sensitive techniques to detect minimal residual disease (MRD) may allow better estimates of the leukemia burden and help the selec
## Abstract Two highly sensitive methods, multiparameter flow cytometry (MFC) and realβtime quantitative PCR (RQβPCR), are increasingly used to monitor minimal residual disease (MRD) and to guide riskβadapted management in acute myeloid leukemia (AML). An independent prognostic impact has been demo