Frequent losses of heterozygosity observed at several chromosomal loci in primary lung cancers have indicated the existence of several tumor suppressor genes associated with this type of cancer. We have examined loss of heterozygosity on chromosomal arm 8p in 49 cases of non-small cell lung carcinom
Detailed deletion mapping of the short arm of chromosome 3 in small cell and non-small cell carcinoma of the lung
β Scribed by Hosoe, S; Shigedo, Y; Ueno, K; Tachibana, I; Osaki, T; Tanio, Y
- Book ID
- 123188859
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 159 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0169-5002
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Several somatic genetic alterations have been described in non-small-cell lung carcinomas (NSCLC). Recurrent chromosomal deletions have suggested the presence of tumor-suppressor genes specifically involved in lung carcinogenesis. For one of these, 2 non-overlapping regions have been proposed on the
Little is known about the biology of Merkel cell carcinoma (MCC), also called small cell carcinoma of the skin. MCC has similarities with small cell lung cancer (SCLC): both are neuroendocrine malignancies with early metastasis t o distant sites and a poor prognosis. Small cell lung cancer biopsies
Forty-eight samples of primary non-small-cell lung cancer (NSCLC) and normal tissue from the same patients were analyzed for allelic deletions on chromosome I I p. Five polymorphic loci were assessed to determine the incidence of I Ip sequence deletions and to define hot-spots of deletions. Informat