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Desymmetrization of dimethyl 3-substituted glutarates through enzymatic ammonolysis and aminolysis reactions

✍ Scribed by Mónica López-Garcı́a; Ignacio Alfonso; Vicente Gotor

Book ID: 104359636
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 157 KB
Volume: 14
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(02)00869-8

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✦ Synopsis

The desymmetrization of differently 3-substituted glutarates through enzymatic aminolysis and ammonolysis has been studied. The effect of the diester and nucleophile structures, the enzymatic preparation as well as the reaction conditions have been compared in terms of both the chemical yield and enantiomeric excess of the corresponding monoamide products.

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