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Designing Selective, High Affinity Ligands of 5-HT 1D Receptor by Covalent Dimerization of 5-HT 1F Ligands Derived From 4-Fluoro- N -[3-(1-methyl-4-piperidinyl)-1 H -indol-5-yl]benzamide

โœ Scribed by Choi, Seok-Ki; Green, David; Ho, Anne; Klein, Uwe; Marquess, Daniel; Taylor, Robert; Turner, S. Derek


Book ID
127123657
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
269 KB
Volume
51
Category
Article
ISSN
0022-2623

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(R)-3-(N-Methylpyrrolidin-2-ylmethyl)-5-
โœ Ian Egle; Neil MacLean; Lidia Demchyshyn; Louise Edwards; Abdelmalik Slassi; Ash ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 125 KB

A series of (R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives (2) have been prepared using parallel synthesis, and their structure-activity relationship studied. High affinity human 5-HT 1B/1D (h5-HT 1B/1D ) ligands have been identified.