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(R)-3-(N-Methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity h5-HT1B/1D ligands

✍ Scribed by Ian Egle; Neil MacLean; Lidia Demchyshyn; Louise Edwards; Abdelmalik Slassi; Ashok Tehim

Book ID: 104364084
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 125 KB
Volume: 13
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(03)00779-0

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✦ Synopsis

A series of (R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives (2) have been prepared using parallel synthesis, and their structure-activity relationship studied. High affinity human 5-HT 1B/1D (h5-HT 1B/1D ) ligands have been identified.

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## Abstract For Abstract see ChemInform Abstract in Full Text.

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