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3-(2-Pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity human 5-HT1B/1D ligands

✍ Scribed by Ian Egle; Neil MacLean; Lidia Demchyshyn; Louise Edwards; Abdelmalik Slassi; Ashok Tehim


Book ID
108073162
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
144 KB
Volume
14
Category
Article
ISSN
0960-894X

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(R)-3-(N-Methylpyrrolidin-2-ylmethyl)-5-
✍ Ian Egle; Neil MacLean; Lidia Demchyshyn; Louise Edwards; Abdelmalik Slassi; Ash πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 English βš– 125 KB

A series of (R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives (2) have been prepared using parallel synthesis, and their structure-activity relationship studied. High affinity human 5-HT 1B/1D (h5-HT 1B/1D ) ligands have been identified.