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Designed Peptide Analogues of the Potassium Channel Blocker ShK Toxin †

✍ Scribed by Lanigan, Mark D.; Pennington, Michael W.; Lefievre, Yann; Rauer, Heiko; Norton, Raymond S.

Book ID
127024659
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
321 KB
Volume
40
Category
Article
ISSN
0006-2960

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Secondary structure of ShK toxin, a pota
Secondary structure of ShK toxin, a potassium-channel-blocking peptide
✍ William R. Kem; Gautam Sanyal; Robert W. Williams; Michael W. Pennington 📂 Article 📅 1996 🏛 Springer Netherlands 🌐 English ⚖ 265 KB

Sea anemones possess small K-channel-blocking peptides about the same size as the scorpion K-channel toxins. We have estimated the secondary structure content (33% helix, 26% ]3-sheet) of one of these toxins, ShK toxin, using CD, Raman, and FTIR spectroscopy. A hypothetical 3D structure of the pepti