Assignment of the three disulfide bonds
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Jan Pohl; Frantisek Hubalek; Michael E. Byrnes; Kurt R. Nielsen; Amina Woods; Mi
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Article
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1995
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Springer Netherlands
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English
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ShK toxin, a 35-residue peptide isolated from the Caribbean sea anemone Stichodactyla helianthus, is a potent inhibitor of the Kv1.3 potassium channel in lymphocytes. The natural toxin contains three disulfide bonds. The disulfide pairings of the synthetic ShK toxin were elucidated as a prerequisite