Synthesis of novel amides and esters prodrugs of olmesartan is described. Their in vitro stability in rat plasma was tested. The results showed that the ester derivative IIa with n-octyl substituted dioxolone moiety was rapidly converted into olmesartan within 30 min. The pharmacokinetic parameters
โฆ LIBER โฆ
Design, synthesis, bioconversion, and pharmacokinetics evaluation of new ester prodrugs of olmesartan
โ Scribed by Jeong-Soo Chang; Mohammed I. El-Gamal; Woong San Lee; Hanan S. Anbar; Hye Jin Chung; Hyun-Il Kim; Young-Jin Cho; Bong Sang Lee; Sun Ahe Lee; Ji Yun Moon; Dong Jin Lee; Hong-Ryeol Jeon; Jaehwi Lee; Young Wook Choi; Chang-Hyun Oh
- Book ID
- 113582962
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 310 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0223-5234
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Novel amides and esters prodrugs of olme
โ
Jin-Hun Park; Jeong-Soo Chang; Mohammed I. El-Gamal; Won-Kyoung Choi; Woong San
๐
Article
๐
2010
๐
Elsevier Science
๐
English
โ 560 KB
Carbamate ester prodrugs of dopaminergic
โ
Kristian T. Hansen; Peter Faarup; Hans Bundgaard
๐
Article
๐
1991
๐
John Wiley and Sons
๐
English
โ 653 KB
Synthesis and evaluation of amino acid e
โ
Dae-Kee Kim; Namkyu Lee; Guang Jin Im; Young-Woo Kim; Kieyoung Chang; Hun-Taek K
๐
Article
๐
1996
๐
Elsevier Science
๐
English
โ 331 KB
Design, Synthesis, and Evaluation of Pro
โ
Singh, Sheo B.; Rindgen, Diane; Bradley, Prudence; Cama, Lovji; Sun, Wanying; Ha
๐
Article
๐
2013
๐
American Chemical Society
๐
English
โ 494 KB
Synthesis and evaluation of Ketorolac es
โ
Hea-Jeong Doh; Won-Jea Cho; Chul-Soon Yong; Han-Gon Choi; Jung Sun Kim; Chi-Ho L
๐
Article
๐
2003
๐
John Wiley and Sons
๐
English
โ 145 KB
Alkyl esters of ketorolac were synthesized as potential prodrugs for transdermal delivery and evaluated to determine the relationship between their skin permeation characteristics and their physicochemical properties. Solubility of the prodrugs in various vehicles was determined at room temperature
Galactosyl Prodrug of Ketorolac: Synthes
โ
Curcio, Annalisa; Sasso, Oscar; Melisi, Daniela; Nieddu, Maria; La Rana, Giovann
๐
Article
๐
2009
๐
American Chemical Society
๐
English
โ 262 KB