Synthesis of novel amides and esters prodrugs of olmesartan is described. Their in vitro stability in rat plasma was tested. The results showed that the ester derivative IIa with n-octyl substituted dioxolone moiety was rapidly converted into olmesartan within 30 min. The pharmacokinetic parameters
โฆ LIBER โฆ
Carbamate ester prodrugs of dopaminergic compounds: Synthesis, stability, and bioconversion
โ Scribed by Kristian T. Hansen; Peter Faarup; Hans Bundgaard
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 653 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0022-3549
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