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Design, synthesis and X-ray crystallographic studies of [7.3.1] and [8.3.1] macrocyclic FKBP-12 ligands

✍ Scribed by Robert E. Babine; T.M. Bleckman; Ethel S. Littlefield; Hans E. Parge; L.A.K. Pelletier; Cristina T. Lewis; Judy V. French; Michael Imbacuan; Susumo Katoh; John H. Tatlock; Richard E. Showalter; J.Ernest Villafranca

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 345 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00032-7

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✦ Synopsis

The design, synthesis, and structure activity relationships of a series of novel macrocyclic FKBP-12 ligands 1 are reported. The crystal structure of the complex between 7 and human FKBP-12 is reported and some SAR results are discussed based on this complex.

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