The design, synthesis, and structure activity relationships of a series of novel macrocyclic FKBP-12 ligands 1 are reported. The crystal structure of the complex between 7 and human FKBP-12 is reported and some SAR results are discussed based on this complex.
Design, synthesis and X-ray crystallographic studies of novel FKBP-12 ligands
β Scribed by Robert E. Babine; T.M. Bleckman; C.R. Kissinger; R. Showalter; L.A. Pelletier; C. Lewis; Kathleen Tucker; Ellen Moomaw; H.E. Parge; J.Ernest Villafranca
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 393 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A novel family of crown ethers, containing adamantane units in the cyclic framework, has been designed and synthesized by a straightforward one-step procedure. The design strategy permits the incorporation of a variety of a-amino acids to provide adamantane-constrained chiral crown ethers for use as
Seven 6, [1,51diazocines 2 with different substituents at position 13 have been prepared from o-(triphenylphosphoranylideneamino)benzaldehyde I and the corresponding aliphatic and aromatic primary amines in yields ranging from 40 to 80%. The molecular and crystal structures of componds 2d (R = 4 H3