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Design, Synthesis, and Tripeptidyl Peptidase II Inhibitory Activity of a Novel Series of ( S )-2,3-Dihydro-2-(4-alkyl-1 H -imidazol-2-yl)-1 H -indoles

✍ Scribed by Breslin, Henry J.; Miskowski, Tamara A.; Kukla, Michael J.; Leister, William H.; De Winter, Hans L.; Gauthier, Diane A.; Somers, Maria V. F.; Peeters, Daniëlle C. G.; Roevens, Peter W. M.

Book ID
121453896
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
258 KB
Volume
45
Category
Article
ISSN
0022-2623

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Efficient synthesis of 3-(4,5-dihydro-1H
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A simple method for the synthesis of various 3-(4,5-dihydro-1H-imidazole-2-yl)-1H-indoles is described. Treatment of different substituted indoles with 1-acetyl-imidazolidin-2-one in the presence of phosphorus oxychloride afforded after hydrolysis in ethanol the corresponding 3-(4,5-dihydro-1H-imida

ChemInform Abstract: Efficient Synthesis
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