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Efficient synthesis of 3-(4,5-dihydro-1H-imidazole-2-yl)-1H-indoles

✍ Scribed by Ulrike Hary; Ulrike Roettig; Michael Paal

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 64 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00960-1

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✦ Synopsis

A simple method for the synthesis of various 3-(4,5-dihydro-1H-imidazole-2-yl)-1H-indoles is described. Treatment of different substituted indoles with 1-acetyl-imidazolidin-2-one in the presence of phosphorus oxychloride afforded after hydrolysis in ethanol the corresponding 3-(4,5-dihydro-1H-imidazole-2-yl)-1H-indoles in moderate to good yields.

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