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Design, Synthesis, and Pharmacology of a Highly Subtype-Selective GluR1/2 Agonist, ( RS )-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic Acid (Cl-HIBO)

✍ Scribed by Bjerrum, Esben J.; Kristensen, Anders S.; Pickering, Darryl S.; Greenwood, Jeremy R.; Nielsen, Birgitte; Liljefors, Tommy; Schousboe, Arne; Bräuner-Osborne, Hans; Madsen, Ulf


Book ID
126058663
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
107 KB
Volume
46
Category
Article
ISSN
0022-2623

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✍ Tommy N. Johansen; Venkataraman Balasubramanian; Ulf Madsen; John W. Ferkany; Po 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 329 KB 👁 2 views

RS)-2-Amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA) is a potent and selective agonist at the NMDA subgroup of excitatory amino acid receptors. To probe its interaction with these receptors we have developed a synthesis of [3H]AMAA. Bromination of a protected form of AMAA with NBS follo