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Design, synthesis, and pharmacological evaluation of ultrashort- to long-acting opioid analgesics

✍ Scribed by Feldman, Paul L.; James, Michael K.; Brackeen, Marcus F.; Bilotta, Joanne M.; Schuster, Suzanne V.; Lahey, Avis P.; Lutz, Michael W.; Johnson, M. Ross; Leighton, H. Jeff


Book ID
118004261
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
895 KB
Volume
34
Category
Article
ISSN
0022-2623

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Design, synthesis, and pharmacological e
✍ Feldman, Paul L.; James, Michael K.; Brackeen, Marcus F.; Bilotta, Joanne M.; Sc πŸ“‚ Article πŸ“… 1991 πŸ› American Chemical Society 🌐 English βš– 895 KB

In an effort to discover a potent ultrashort-acting mu opioid analgetic that is capable of metabolizing to an inactive species independent of hepatic function, several classes of 4-anilidopiperidine analgetics were synthesized and evaluated. One series of compounds displayed potent mu opioid agonist