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Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates

✍ Scribed by Yolanda Karla Cupertino da Silva; Cristina Villarinho Augusto; Maria Letícia de Castro Barbosa; Gabriela Muniz de Albuquerque Melo; Aline Cavalcanti de Queiroz; Thays de Lima Matos Freire Dias; Walfrido Bispo Júnior; Eliezer J. Barreiro; Lídia Moreira Lima; Magna Suzana Alexandre-Moreira


Book ID
108072862
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
457 KB
Volume
18
Category
Article
ISSN
0968-0896

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Synthesis and pharmacological evaluation
✍ Angeliki P. Kourounakis; Dimitrios Galanakis; Karyofillis Tsiakitzis; Eleni A. R 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB 👁 2 views

The role of reactive oxygen species in inflammatory processes has been well documented, while several antioxidant compounds have been shown to exhibit anti-inflammatory activity. We designed novel compounds as potential agents that combine enhanced antioxidant and anti-inflammatory activities. Deriv