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Design, Synthesis, and Evaluation of Proline and Pyrrolidine Based Melanocortin Receptor Agonists. A Conformationally Restricted Dipeptide Mimic Approach

✍ Scribed by Tian, Xinrong; Field, Timothy B.; Switzer, Adrian G.; Mazur, Adam W.; Ebetino, Frank H.; Wos, John A.; Berberich, Steve M.; Jayasinghe, Lalith R.; Obringer, Cindy M.; Dowty, Martin E.; Pinney, Beth B.; Farmer, Julie A.; Crossdoersen, Doreen; Sheldon, Russell J.


Book ID
118036684
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
303 KB
Volume
49
Category
Article
ISSN
0022-2623

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Synthesis of a conformationally restrict
✍ Wim M De Borggraeve; Frederik J.R Rombouts; Erik V Van der Eycken; Suzanne M Top πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 84 KB

Dichloropyrazinone 3 was converted into a conformationally restricted dipeptide analogue 8 by means of a Diels-Alder strategy. The b-turn characteristics of molecule 8 were examined by molecular modeling and NMR spectroscopy.