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Design, synthesis, and evaluation of orally active fibrinogen inhibitors

✍ Scribed by Akito Tanaka; Hiroyoshi Sakai; Takatoshi Ishikawa; Toshiaki Aoki; Yukio Motoyama; Hisashi Takasugi

Book ID: 104364869
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 372 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(97)00055-3

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✦ Synopsis

Low molecular weight and orally active fibrinogen inhibitors are described. The compounds studied in this work were rationally designed based on a metabolic study of a peptidic fibrinogen inhibitor, 4-(4amidinophenoxy)butanoylaspartylvaline (1, FK633), which led to the synthesis of a potent and orally active antiplatelet agent, 4-(4-amidinophenoxy)butanoylaspartylvalylthiomorpholine l, 1-dioxide (3 f, FR 15 8999).

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