Design and synthesis of potent, orally active, inhibitors of carboxypeptidase U (TAFIa)
✍ Scribed by Magnus O. Polla; Louise Tottie; Carita Nordén; Marcel Linschoten; Djordje Müsil; Susanne Trumpp-Kallmeyer; Inger R. Aukrust; Rune Ringom; Kjetil H. Holm; Siren M. Neset; Marcel Sandberg; John Thurmond; Peng Yu; Georgeta Hategan; Herb Anderson
- Book ID
- 118275932
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 650 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0968-0896
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📜 SIMILAR VOLUMES
Low molecular weight and orally active fibrinogen inhibitors are described. The compounds studied in this work were rationally designed based on a metabolic study of a peptidic fibrinogen inhibitor, 4-(4amidinophenoxy)butanoylaspartylvaline (1, FK633), which led to the synthesis of a potent and oral
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