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Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation

✍ Scribed by Wen Luo; Yan-Ping Li; Yan He; Shi-Liang Huang; Jia-Heng Tan; Tian-Miao Ou; Ding Li; Lian-Quan Gu; Zhi-Shu Huang


Book ID
108072975
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
729 KB
Volume
19
Category
Article
ISSN
0968-0896

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✍ Isabel Dorronsoro; Diana Alonso; Ana Castro; Maria del Monte; Esther García-Palo 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 125 KB 👁 2 views

## Abstract The synthesis of tacrine‐thiadiazolidinone hybrids is described. These compounds are designed as dual acetylcholinesterase inhibitors binding simultaneously to the peripheral and catalytic sites of the enzyme. All tested compounds exhibit significant AChE inhibitory activity. Competitio