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Design, Synthesis and Evaluation of Antidepressant Activity of Novel 2-Methoxy 1, 8 Naphthyridine 3-Carboxamides as 5-HT 3 Receptor Antagonists

✍ Scribed by Mahesh, Radhakrishnan; Dhar, Arghya Kusum; Jindal, Ankur; Bhatt, Shvetank


Book ID
121837109
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
635 KB
Volume
83
Category
Article
ISSN
1747-0277

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A novel series of 3-ethoxyquinoxalin-2-carboxamides were designed as per the pharmacophoric requirements of 5-HT 3 receptor antagonist using ligand-based approach. The desired carboxamides were synthesized from the key intermediate, 3-ethoxyquinoxalin-2-carboxylic acid by coupling with appropriate a