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Ligand-Based Design, Synthesis, and Pharmacological Evaluation of 3-Methoxyquinoxalin-2-carboxamides as Structurally Novel Serotonin Type-3 Receptor Antagonists

✍ Scribed by Radhakrishnan Mahesh; Thangaraj Devadoss; Arghya Kusum Dhar; Sudali Muthu Venkatesh; Sourabh Mundra; Dilip Kumar Pandey; Shvetank Bhatt; Ankur Kumar Jindal


Book ID
112002496
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
233 KB
Volume
345
Category
Article
ISSN
0365-6233

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A novel series of 3-ethoxyquinoxalin-2-carboxamides were designed as per the pharmacophoric requirements of 5-HT 3 receptor antagonist using ligand-based approach. The desired carboxamides were synthesized from the key intermediate, 3-ethoxyquinoxalin-2-carboxylic acid by coupling with appropriate a